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10.13586/j.cnki.yjyx1984.2013.04.089 177 ZhangL

In rare cases, especially with high doses or improper administration, more serious side effects can occur, such as issues affecting the liver or kidneys

In humans, the administration of high doses of VC intravenously for 48 h (50 mg/kg every 6 h) has been shown to reduce the plasma syndecan-1 concentration (129)

Despite the incredible advancements in wound care and regenerative medicine, key agenciesincluding the Centers for Medicare & Medicaid Services (CMS), the Food and Drug Administration (FDA), and the Agency for Healthcare Research and Quality (AHRQ)still lack a unified, standardized definition of what constitutes a "skin substitute." They actually rely on a list of surgical procedures to define products, The CPT manual, which explicitly states it does define products

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