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Role of v3 Integrin in Phagocytosis In vitro studies show that v3 integrin triggers Rac1-mediated signaling events in HTM cells associated with glaucoma

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Based on this pharmacokinetic profile, administration of cagrilintide to participants with varying degrees of renal or hepatic impairment is expected to yield comparable exposure across dose levels and dosing frequencies, without compromising safety

Jurek B, Neumann ID