The mechanism makes physiological sense
The findings, which were presented over the weekend at ENDO 2026, the Endocrine Society's annual meeting, were based on an analysis of health records from more than 42,000 adults who were already taking at least two types of blood pressure medications when they began treatment with GLP-1 drugs such as semaglutide, tirzepatide or liraglutide
Theres no official guidance from manufacturers on how to taper off a GLP-1, but your clinician will be able to guide you here, setting milestones, creating a schedule, and monitoring your weight
And we are applying that information now to the GLP-1 users who want to go off the medication yet to be studied in more detail
Activation of the renal GLP-1R leads to expression of Ren1 in the renal vascular tree