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This paper highlights the important molecular features of SOD1-ALS, which is not a TDP-43 proteinopathy and may partially explain why treatments evaluated in SOD1 -transgenic mouse models have not generally translated well to the clinic

If 1,000 mcg of peptide is dissolved in 2 mL of bacteriostatic water, the concentration is calculated like this: Concentration = Total peptide amount Total solution volume 1,000 mcg 2 mL = 500 mcg/mL This means each milliliter of solution contains 500 mcg of peptide

RNA sequencing Sequencing libraries were generated using the NEBNext UltraTM RNA Library Prep Kit for Illumina following the manufacturers recommendations, and index codes were added to attribute sequences to each sample

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Clinically prescribed injectable peptides are legal when compounded by an FDA-registered pharmacy and prescribed by a licensed medical provider