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Further, the text of the proposed regulation in the CY 2026 PFS proposed rule (90 FR 32854) included a proposed revision to the introductory text of 425.316(c)(2), to limit the applicability of this provision to performance years beginning on or after January 1, 2021 and before January 1, 2026, that was not described in preamble

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They should be considered adjuncts, not replacements, to lifestyle and medical care

Quick answer: In the Phase 2 clinical trial (Jastreboff et al., 2023, New England Journal of Medicine ), retatrutide was given by once-weekly subcutaneous injection across a 112mg range