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The evidence base for tirzepatide as monotherapy is robust, with pivotal trials including SURMOUNT-1 demonstrating significant weight reduction in adults with obesity, and SURPASS trials establishing glycemic efficacy in type 2 diabetes

[190] This effect held irrespective of concomitant SGLT2 inhibitor use, indicating additive kidney protection

ROS plays a crucial role in various bodily functions by regulating cell growth, differentiation, progression, and cell death and, thus, their balance is required in the body

Chronic stress raises cortisol levels, which can interfere with weight loss and promote fat storage, especially around the midsection

[] Lynam et al [] reported the discrimination and calibration of seven models of type 1 and type 2 diabetes using regression modeling to machine learning