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58,59 The Role of the Microbiome The community of microorganisms that inhabit the intestines, referred to as the gut microbiota, is increasingly being recognized as an important regulator of such fundamental body processes as digestion, immune function, metabolic function, behavior, mood, food preference, and appetite

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The balance between ACE and ACE2 activity influences the ultimate effect of RAAS, since ANG II promotes vasoconstriction and proliferation while ANG (1,7) stimulates vasodilation and apoptosis ( Recently, three new axes have been identified, emphasizing the role of the kidney in this picture ( The ACE2/ANG(1-7)/Mas receptor pathway ( The prorenin/PRR/MAP kinases ERK1/2 axis: in the past years, renin was considered simply as an enzyme catalyzing the conversion of AGT into ANG I

All authors revised the results and reviewed the manuscript

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