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In traditional Meibomian gland dysfunction (MGD) the oil inside the Meibomian glands, which in normal, healthy glands have the consistency of, and flows like, olive oil becomes viscous (with a thicker, firmer consistency like lard), clogging the glands, resulting in back pressure which stresses the glands causing the glands to shorten, atrophy, and ultimately be lost

Nair MP, Mahajan S, Reynolds JL (2006) The flavonoid quercetin inhibits proinflammatory cytokine (Tumor Necrosis Factor Alpha) gene expression in normal peripheral blood mononuclear cells via modulation of the NF-kappa B system

doi: 10.1038/s41416-020-01156-1 55 SchiliroCFiresteinBL

HSP-based DNA vaccines and tolerance induction HSP-directed DNA vaccines provide an immunologically sophisticated strategy aimed at restoring tolerance rather than broadly suppressing immunity