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The apoE / mice fed with dietary TMAO for 8 weeks were found to have increased atheromatous plaques in the aorta and elevated serum lipids compared to the control group, which was demonstrated to be due to the inhibition of hepatic bile acid synthesis in mice possibly by downregulating Cyp7a1 (i.e., cholesterol 7-hydroxylase, the key regulatory enzyme of hepatic bile acid biosynthesis) (Koeth et al

For each analysis in Table 2 and for the unmatched analysis of MOF, we also present Kaplan-Meier survival curves for crude illustrations ( Figure 2 ), which yielded non-significant results in all analyses of the matched cohort

Fasting metformin concentrations were measured after the washout period at baseline (day 1, visit 2) and after the 3 month study (day 1, visit 5) ~12 h after the last study dose (ESM Table 1)

( c ) Data represent mean normalized to Control-Ab for the corresponding route of administration