albicans was formed in 96 well glass-like microplate (Cellvis, Sunnyvale, CA, United States) and incubated for 24 h at 37C with M3 or M4 at concentrations in the range of 3.112.5 M or 12.5100 M, respectively, diluted in 100 l of RPMI 1640
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Introduction Several studies have concluded that oxidative stress, due to increased production of reactive oxygen species (ROS), for instance, because of infection, can trigger inflammation, although the concept has been considered an oversimplification ( While in the context of oxidative stress GSH acts as an antioxidant ROS scavenger, in the context of redox regulation the couple GSH/GSSG (oxidized GSH) acts as a signaling molecule that regulates protein function via thioldisulfide exchange reactions including protein glutathionylation ( To investigate the role of endogenous GSH in inflammation, whether it acts as an antioxidant or a signaling molecule, we used the mouse macrophage RAW cell line stimulated with lipopolysaccharide (LPS) with and without pretreatment with the GSH synthesis inhibitor buthionine sulfoximine (BSO)
Monitoring & Complementary Add-Ons (15-20 min) Vital signs are monitored at 10-minute intervals throughout the infusion
