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Counsel patients on the importance of returning for follow-up blood tests every 3 to 6 months to confirm adequacy of therapy [see Dosage and Administration (2.3)]

Methionine: This amino acid in the b12 mic dosage aids in the breakdown of fats by preventing excess fat accumulation in the liver

Subsequently, clinical studies with pembrolizumab, another anti-PD-1 monoclonal antibody, in mCRPC patients also proved ineffective, indicating that monotherapy with PD-1 inhibitors in this patient population did not yield significant objective responses (Scheid et al., 2016)

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