This isn't a minor variable: dietary nicotinamide can saturate NNMT binding sites within 6090 minutes of a meal, reducing the peptide's effective concentration at the target enzyme
References: Vukojevi, J., Milavi, M., Perovi, D., Ili, S., Zemba ili, A., uran, N., trbe, S., Zorii, Z., Filipi, I., Brei, P., Seiverth, S., & Sikiri, P
Inflammation Support: This combination may help reduce inflammatory activity and oxidative stress, supporting a smoother recovery process
Its important to note that while some people seek B12 supplementation for wellness, the benefits in non-deficient individuals are not strongly supported by evidence
Parsons is recommending the oral form of methylated B12 as a back up