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Common adverse effects include gastrointestinal symptoms such as nausea, vomiting, diarrhea, and constipation, which typically diminish with gradual dose titration

Selective estrogen receptor modulators (SERMs) are a class of compounds that inhibit the estrogen signaling pathway and cell cycle progression, which consequently inhibits cell growth [6]

Besides the -cell dysfunction, incretin deficiency is now considered among the key factors in the pathophysiology of T2D

Patients with a body mass index (BMI) of 30 or higher, or BMI of 27 or higher with weight-related health conditions like hypertension or type 2 diabetes, generally qualify for GLP-1 treatment

If side effects are significant, staying at each dose level for six weeks instead of four allows more time for adaptation