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The review would benefit from a bit more text on how this notion impacts the balance between desired therapeutic effects, "diluted" effects from dimer-mediated versus non-dimer effects, and undesired off-target effects (which are discussed some in terms of receptor specificity, but not in terms of anatomy, where the same dimer may have different effects in different brain regions). Response: We have added a new section title General treatment approaches before the concluding remarks

It might feel like your skin is getting worse, but whats really happening is that those impurities are surfacing all at once instead of over time

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The strongest evidence comes from older adults and people with increased oxidative stress , whose glutathione levels are often lower

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