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TOPI inhibitor-induced SSBs require tyrosyl-DNA phosphodiesterase 1 (TDP1)-mediated excision repair and homologous recombination pathways for repair, so mCRPC tumors harboring HRD may exhibit increased sensitivity to TOPI inhibitor-carrying ADCs 36,37

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Most patients have not been told them

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Erythropoietin deficiency in CKD is the typical mechanism, but the code assignment follows the providers clinical statement