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These medications are FDA-approved for chronic weight management in adults with a BMI of 30 or greater (obesity) or a BMI of 27 or greater (overweight) with at least one weight-related health condition such as hypertension, type 2 diabetes, or high cholesterol

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At the highest doses used for obesity treatment (2.4 mg semaglutide, 15 mg tirzepatide), the medication may overwhelm certain regulatory mechanisms and produce paradoxical sensitization

Adults who have a body mass index (BMI) of at least 30 or who have a BMI between 27 and 30 as well as at least one weight-related health condition, such as heart disease, high cholesterol, or high blood pressure, are eligible for a prescription in consultation with their doctor