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Semaglutide and tirzepatide do not directly cause muscle wasting

If the underlying disease process has resolved and cobalamin body stores have been replenished, serum cobalamin concentration should be supranormal [higher than normal] at the time of reevaluation

Dejgaard TF, Schmidt S, Frandsen CS et al (2020) Liraglutide reduces hyperglycaemia and body weight in overweight, dysregulated insulin-pump-treated patients with type 1 diabetes: the Lira Pump triala randomized, double-blinded, placebo-controlled trial

Results Search results Of the 1445 articles obtained in the initial database search, 976 were identified based on their titles and abstracts

However, preclinical studies demonstrate therapeutic effects with once-daily or even less frequent administration, suggesting tissue distribution, receptor binding, or cellular signaling effects extend beyond plasma clearance