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Gastrointestinal Side Effects Over Time Nausea, vomiting, diarrhea, and constipation are the most common side effects of GLP-1 therapy

aleniglipron and orforglipron) are functionally Gs-biased and recruit -arrestin poorly (which is typically involved in turning off the GLP-1 receptor's signal by promoting internalization and downregulation and mediating nausea and vomiting)

Muscle Mass Reduction Studies indicate that up to 40% of weight loss on some GLP-1 medications can actually be lean muscle rather than fat tissue

Post-market surveillance and real-world data from millions of GLP-1 prescriptions have not identified a widespread gastroparesis epidemic

Why GLP-1 drugs may help treat lymphedema Weight gain worsens lymphedema, but many breast cancer survivors must take hormone blockers, which can lead them to put on weight, Dayan says