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doi: 10.1016/s0168-8278(02)00306-9

Intriguingly, both regulatory pathways are not responsive to iron directly, but instead react to Fe-S cluster levels 133

The Reed model provides a comprehensive mathematical representation of one-carbon GSH metabolism, boasting the inclusion of the transsulfuration pathway, as well as glutathione synthesis, transport and breakdown

Subsequent studies confirmed senolytic activity in additional cell types including chondrocytes, Leydig cells, keloid fibroblasts, and endothelial cells demonstrating that the FOXO4-p53 dependency is a conserved feature across multiple senescent cell populations