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Figure 1: Folate metabolism starts with polyglutamate folates (a form of Vitamin B9), which are broken down by the enzyme dihydrofolate reductase (DHFR) into dihydrofolate and then tetrahydrofolate (THF)

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Participants did not report any adverse effects, there were no abnormalities in blood tests taken during the trial and the mens prostate examination results remained stable