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Finally, administration of SGLT-2i to patients with DM and a recent AMI was shown to reduce the progression of renal dysfunction [17]
The GLP-1 component slots into a broader framework built around sustainable, long-term results
Since 2015, large-scale cardiovascular outcome trials (CVOTs) have demonstrated that sodium-glucose cotransporter-2 inhibitors (SGLT2i) and glucagon-like peptide-1 receptor agonists (GLP-1 RAs) significantly reduce the risk of major adverse cardiovascular events, cardiovascular mortality, and heart failure hospitalization in patients with T2DM and established cardiovascular disease or high-risk profiles
For instance, Wegovy (specifically approved for weight management) has demonstrated impressive results in clinical trials, with many patients losing substantial percentages of their body weight
Metabolic dysfunction-associated fatty liver disease (MAFLD)-rather a bystander than a driver of mortality
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