Experts recommend taking B12 supplements with a glass full of water to optimize absorption
[1] Because intrinsic-factor-dependent uptake in the distal ileum can be absent in conditions such as autoimmune gastritis, pancreatic insufficiency, or bariatric surgery, the intramuscular or subcutaneous route bypasses gastrointestinal barriers and reliably restores serum concentrations
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It is also important to note that the Food and Drug Administration (FDA) may not have approved all of these uses, so a thorough risk-benefit assessment should be undertaken by the prescriber
Gastrointestinal Conditions: Disorders like Crohn's disease, celiac disease, or atrophic gastritis can impair absorption