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Genetics (2009) 182(2):56574

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"Cobalamin coenzyme forms are not likely to be superior to cyano- and hydroxyl-cobalamin in prevention or treatment of cobalamin deficiency." Molecular Nutrition & Food Research , 2015

Animal Model:Ovariectomized female mice of the SW strain [6] Dosage:62.5-2000 g Administration:Intravaginal injection Result:Stimulated a vaginal response similar to that caused by estrogen, resulting in a decrease in intravaginal tetrazolium, increased epithelial growth, and keratinization

It is a weak acid and as such does not completely dissociate in water so the intact and dissociated forms are in equilibrium in solution