Several FXR agonists that have been assessed in clinical trials and their effects are: Obeticholic Acid (OCA): A derivative/synthetic variant of bile acid, it improves insulin sensitivity, liver inflammation, hepatocellular ballooning and reduces fibrosis (218)
Nauck MA, Meier JJ, Cavender MA, et al
Develop the habit of returning the vial immediately after use
Collectively, these findings demonstrate that SLE is characterized by mTOR pathway hyperactivation and distinct T cell metabolic reprogramming favoring glycolysis and FAS, which disrupts Th17/Treg balance and drives autoimmunity, positioning metabolic intervention as a viable treatment strategy
Dietary intervention has a significant impact on the composition of the gut microbiota