These convert phosphatidylinositol2-phosphate (PIP2) into phosphatidylinositol-3-phosphate (PIP3) and, by so doing, activates protein kinase B (PKB), the metabolic pathway for glycogen synthesis.1314 In addition to the conversion to phosphatidylinositol-3-phosphate, inositol also acts by activating pyruvate dehydrogenase kinase, isoenzyme 1
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It is a modified derivative of angiotensin IV, a component of the renin-angiotensin system involved in blood pressure regulation and, intriguingly, cognitive function
Furthermore, dual and triple receptor agonists, such as tirzepatide and retatrutide, offer additional advantages by targeting multiple pathways involved in energy regulation, resulting in enhanced weight loss and improved metabolic outcomes compared to traditional GLP-1 RAs
EP thanks the NRF of South Africa (grant number 142142) and SA MRC (self-initiated research (SIR) grant)
