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Gut microbiota-dependent trimethylamine N-oxide (TMAO) pathway contributes to both development of renal insufficiency and mortality risk in chronic kidney disease

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1).11,12 However, in clinical practice, detection of albuminuria is still insufficient.7 In this context, it is a priority to improve early detection strategies, including urine albumin-creatinine ratio tests.11 Most clinical practice guidelines recommend annual screening for CKD in the patient with DM