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The SUMMIT trial, involving 731 individuals with HFpEF and obesity followed for a median of 104 weeks, revealed a 38% decrease in the composite endpoint of cardiovascular mortality or heart-failure deterioration events (HR: 0.62, 95%CI: 0.41-0.95, P = 0.026), driven primarily by fewer worsening heart-failure events (8.0% vs

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Luo X., Zhu D., Li J., et al., Selection of the Optimal Dose of Sertraline for Depression: A DoseResponse MetaAnalysis of Randomized Controlled Trials, Psychiatry Research 327 (2023): 115391

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