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After 12 weeks, all rats underwent a dual-energy X-ray absorptiometry (DEXA) scan using a Hologic QDR 4500 instrument (Hologic, Waltham, MA) which was utilized with a specialized software (version V819a) and a rat-specific internal standard then sacrificed by cervical dislocation

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Unlike TRANSCEND-T2D-1, which specifically targeted a diabetes population, TRIUMPH-2 is a weight management basket trial where participants also have T2D a distinct enrollment design

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