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While these effects initially made GLP-1 seem a promising candidate for drug development, the earliest clinical studies from 1992 and 1993 revealed that GLP-1s half-life in the body was disappointingly short

Saad MJA, Santos A, Prada PO

Early studies focused on single-hormone pathways, particularly GLP-1

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Participant demographics and characteristics for all human studies are detailed in Supplementary Table 1 and 2, respectively

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