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Traditionally, GLP-1 receptor agonists required injection, which limited acceptance among some patients

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Targeting to specific cell types in the brain is challenging, but this new paper uses a bifunctional molecule that delivers an NMDA receptor antagonist to GLP-1 receptor expressing neurons in an effort to treat obesity Targeting to specific cell types in the brain is challenging, but this new paper uses a bifunctional molecule that delivers an NMDA receptor antagonist to GLP-1 receptor expressing neurons in an effort to treat obesity "...our approach demonstrates the feasibility of using peptide-mediated targeting to achieve cell-specific ionotropic receptor modulation..."Previous work had shown that injecting NMDA receptor antagonists into the lateral hypothalamus inhibits food intake and causes a reduction in body weight.But due to brain wide expression of NMDA receptors multiple neuronal circuits are affected, leading to a significant side effects...Which is why the authors fused an existing NMDA receptor antagonist with the now widely popular neuropeptide Glp1

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