Inhibiting NADPH oxidases to target vascular and other pathologies: an update on recent experimental and clinical studies
Funding This work was supported by the NIH/NIDDK R01 DK094907 grant to T.H.L
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Interpretation was difficult because withdrawal itself can produce headache, nausea, dizziness and cardiovascular changes
In certain embodiments, any controlled release otic formulation or composition described herein increases the exposure of a therapeutic agent and increases the Area Under the Curve (AUC) in otic fluids (e.g., endolymph and/or perilymph) by about 30%, about 40%, about 50%, about 60%, about 70%, about 80%, or about 90% compared to a formulation or composition that is not a controlled release otic formulation or composition