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Linagliptin was shown to prevent -cell apoptosis in metabolic and inflammatory stress conditions through the anti-inflammatory interleukin receptor antagonist (IL-1RA) [21]
The traditional model, caloric restriction combined with increased physical activity, remains foundational, but it is increasingly recognized as insufficient on its own for individuals whose metabolic challenges are rooted in gut microbiome dysbiosis rather than simple energy imbalance
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