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Previously, administration of GC via oral, rectal, IV and IM routes was prohibited in-competition due to clear evidence of systemic effects however this ban has now been extended to include any in-competition injection of GC (e.g., intravenous, intramuscular, periarticular, intra-articular, peritendinous, intratendinous, epidural, intrathecal, intrabursal, intralesional (e.g., intrakeloid), intradermal, and subcutaneous)

They never completed the full clinical trial process required for FDA approval

Determination of the thermodegradation of deoxyArbutin in aqueous solution by high performance liquid chromatography

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These can range from mild redness and transient discomfort to more pronounced inflammation with knot formation lasting several days