Further simulations showed that over a wide range of doxorubicin (050 M), the model can be used to suggest the specific concentration and exposure duration required to deplete cytosolic GSH by 70%, the threshold by which antioxidant defence is impaired, protein binding occurs, and cell death is possible
Side effects that interfere with nutrition, hydration, or dose progression
People get impatient and shake the vial to speed up dissolution
This pricing model means your dose may need to go up, but your price won't, removing cost uncertainty as patients titrate toward their therapeutic range
In the single ascending dose study, UA demonstrated bioavailability in plasma across all the tested doses ranging from 250 to 2,000 mg (7)