ASS1 expression has been reported to be decreased or even abolished in many cancers (Dillon et al., 2009), which are thought of as arginine-auxotrophic cancers because of the inability to synthesize arginine and resulting susceptibility to arginine-deprivation therapy
Previous studies have demonstrated the oxidation of gluthathione (GSH) into glutathione disulfide (GSSG) 12 , the oxidation of NADH into NAD + 13 , or the reduction of azides into amines 14
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