1 Introduction Central nervous system (CNS) injuries, including neurodegenerative diseases and stroke, pose a significant global health burden as the leading cause of disability and the second most common cause of death globally ( Ferroptosis, first described in 2012, is an iron-dependent form of regulated cell death characterized by: (1) accumulation of lipid peroxides and reactive oxygen species (ROS), (2) distinct mitochondrial morphology including shrinkage and cristae reduction, and (3) dependence on iron metabolism (Yao et al., 2021)
Some may feel lightheaded or dizzy briefly
Most acute effects are dose- and rate-dependent and improve with slower injection and conservative titration
Seven days after irradiation, mice were euthanized, and the entire large intestine was carefully excised, starting from the cecum (the distal end of the small intestine) to the anal verge
In the subtropical region, the highest concentration was 3.76 mg/kg (9)
