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keeping a food diary can be helpful Practical management tips: Take Mounjaro at a consistent time each week, ideally when you can rest if nausea occurs Consider ginger tea, which some patients find helpful for nausea (discuss with your pharmacist first) Remain upright for at least 30 minutes after eating to reduce reflux symptoms If constipation occurs, increase dietary fibre gradually and maintain adequate fluid intake For persistent nausea, your GP may prescribe anti-emetic medication, though these have important restrictions: Metoclopramide should only be used for short-term treatment (maximum 5 days) [12] [13] Domperidone has cardiac safety restrictions and is only appropriate for certain patients after careful assessment [15] Dose titration considerations: Mounjaro is initiated at a low dose (2.5 mg weekly) and gradually increased every four weeks to minimise side effects

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When selecting a DPP-4 inhibitor for each patient, the clinician should take into account the variations in the pharmacokinetic profile discussed analytically above

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