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To further support the negative impact of meningeal T H 17 immunity on cognitive performance in AD, we assessed the level of T H 17 cells in intestinal-associated tissues of specific-pathogen-free (SPF) relative to germ-free (GF) 5xFAD mice, previously reported to significantly outperform conventional 5xFAD mice in cognitive tests 57

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In NOS-positive ivy cells and SST-positive bi-stratified oriens-lacunisum/moleculare (O-LM) neurons, LTP could be induced by theta-burst stimulation, but LTP was prevented if theta-burst stimulation was paired with depolarization (Szabo et al., 2012)

Vitamin B12 plays a critical role in the bodys energy production, but its deficiency can lead to a host of debilitating symptoms, including tiredness, brain fog, and muscle weakness

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