Oral delivery of chemotherapeutic drugs offers a potential solution, with the benefits of enhanced treatment adherence and patient compliance
Notably, HIF-1 mediates adaptive metabolic responses to hypoxia by enhancing glycolytic pathway, serine synthesis and one-carbon metabolism to promote mitochondrial antioxidant production (NADPH and GSH), and inhibiting the TCA cycle so as to diminish mitochondrial ROS production (247)
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Development 120, 22252234
C: JNK protein levels in control and in HPV-16 E7- and in HPV-16 E7 Mut-expressing HaCaT cells that were untreated or cells that were sampled after induction of oxidative stress by exposure to UV (UVB, 5 mJ/cm 2 for 1 min) with a 5 h recovery period, evaluated using an antibody specific for the phosphorylated form of JNK (pJNK) and another antibody that detects total JNK levels (JNK, performed on a separate twin gel)