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in both instances, the lesions then persist throughout the patients life

The evidence base is anchored by STEP (semaglutide for weight management, The New England Journal of Medicine , 2021), SURMOUNT (tirzepatide for weight management, NEJM 2022), and SURMOUNT-OSA (tirzepatide for obstructive sleep apnea, NEJM 2024)

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DNA was pelleted using phenol/chloroform/isoamyl alcohol (25:24:1) (PCIAA) (Sigma) and isopropanol, and pellets were washed with 70% ethanol and dissolved in UltraPure Distilled Water (Invitrogen)

Without censoring the participants after they started symptomatic therapy (Fig