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When erastin acts on lung cancer A549 cells, it upregulates and activates P53, thereby transcriptionally activating its downstream target genes (including P21 and bax), thereby inhibiting SLC7A11 activity, inducing ROS accumulation and eventually leading to ferroptosis 48

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If validated in subsequent trials across diverse populations, such treatments could help reduce the burden of cardiometabolic disease and improve patients' overall quality of life worldwide