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Beyond their primary role in lipid digestion, bile acids may act as signaling molecules through the Farnesoid X receptor (FXR) and the Takeda G protein-coupled receptor 5 (TGR5), thereby modulating glucose metabolism, insulin sensitivity, and hepatic lipid homeostasis (Targher et al., 2021[75]

The elevated H 2 O 2 concentration drives the balance in the GPX and GR reactions towards GSSG thus lowering the [GSH]/[GSSG] ratio

Around 90% of the over 37 million Americans with diabetes have Type 2 diabetes, a condition associated with obesity, according to the CDC