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Obesity and type 2 diabetes impair insulin-induced suppression of glycogenolysis as well as gluconeogenesis

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Methods and materials This study strictly adhered to the principles outlined in the Declaration of Helsinki and received approval from the institutional review board of the First Affiliated Hospital of Chengdu Medical College

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The expression of the aforementioned pro-inflammatory genes, which were highly upregulated by HFD, was substantially reduced in the HFD + Ret group