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87 Alternatively, hyperexcitable small fiber neurons in PDPN might be more susceptible to bioenergetic failure, increasing distal nerve fiber degeneration

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Further, AngII binding at the AT 1 receptor increased DA neuron degeneration initiated by subthreshold doses of DA neurotoxins by stimulating intraneuronal levels of ROS and neuroinflammation by activation of microglial NADPH oxidase (141144)