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4 Results from ATTAIN-1 at the highest dose (36 mg): An average weight loss of 11.2% on orforglipron vs 2.1% on placebo 54.6% lost at least 10% of their body weight 36% lost at least 15% 18.4% lost 20% or more For people who completed the full 72 weeks, the average weight loss reached 12.4% The ATTAIN-1 trial used a 36 mg capsule

Other Effects: Potential immune modulation, anti-inflammatory properties suggested in some research, and effects on sebaceous glands through MC5R activation

The bill now is expected to cost $1.7 billion over ten years

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