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Leptin resistance is not a formal clinical diagnosis in UK practice, and routine leptin measurement is not recommended to guide GLP-1 agonist therapy
GLP-1 drugs were originally developed to treat type 2 diabetes, but many people now use them as a medicine for weight loss
Nausea, vomiting, diarrhea, and constipation affect a substantial proportion of patients, and they are the primary reason patients discontinue treatment
Discontinuation for adverse events was 6.1% for tirzepatide versus 8.0% for semaglutide [76]
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