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Debido a los beneficios en el control glucmico y en la salud cardiovascular, estos frmacos pueden ser implementados en monoterapia de primera lnea cuando est contraindicada la metformina, en combinacin con otros agentes hipoglucemiantes orales, excepto los IDPP-4, incluso pudindose combinar con insulina..Por otra parte, los IDPP-4, como su nombre lo indica, actan inactivando la enzima proteoltica DPP-4, que es responsable de la degradacin del GLP-1 y el GIP, lo que permite reducir la velocidad de degradacin

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