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Evolving knowledge and therapy of inflammatory bowel disease

(PubMed) Shaw-Smith C, Flanagan SE, Patch AM, et al

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The authors suggested the anti-inflammatory properties of hydrocortisone could stabilize the macrophage lysosomes, though it is possible hydrocortisone is abrogating the inflammatory response by its typical mechanisms: namely, reducing upregulation of inflammatory genes by reversing histone acetylation of those genes through binding of glucocorticoid receptors to coactivators and recruitment of histone deacetylase-2 to the activated transcription complex