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Moreover, 16 weeks of CLA supplementation (8 g oil/d contain 6.4 g/d net CLA without isomers identified) in obese women with diabetes reduced BMI and total adipose mass, but had no effect on lean body mass [78], which could potentially be due to the effect of CLA on PPAR-, as CLA is modest ligand for PPAR- [79]

The diagram below, adapted from the Society of Clinical Research Associates, shows the general timing of HF and clinical studies for combination products

Kloster I, Erichsen MM Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke 2021