But in terms of people who are really grounded in what's real, that he's, he is, I put him in that category whether he likes it or not
B12 shots are usually given into a muscle, like your upper arm or thigh
Structure and dynamics of the active Gs-coupled human secretin receptor

The SCFA-Microglia Connection: How Fiber Becomes Neuroprotection Emerging research is revealing the precise mechanisms by which SCFAs tune microglial phenotype and neuroinflammation through sophisticated molecular pathways: HDAC Inhibition : SCFAs act as histone deacetylase inhibitors, directly changing gene expression in microglia to favor anti-inflammatory, neuroprotective phenotypes over pro-inflammatory ones GPCR Signaling : Through specific G-protein coupled receptors, notably GPR109A, SCFAs send direct signals to microglia to calm neuroinflammation rather than fuel it PPAR-/Nrf2 Activation : SCFAs activate these crucial transcription factors that regulate antioxidant responses and cellular protection TLR4/NF-B Suppression : They actively suppress the inflammatory pathways that drive neurodegeneration Beyond the Gut: SCFAs and Whole-Brain Health Perhaps most remarkably, research demonstrates that SCFAs produced in your colon don't just stay local, they cross into systemic circulation and directly impact brain regions crucial for stress response, mood regulation, and cognitive function

Pozzer A, Zimmermann P, Doering UM, van Aardenne J, Tost H, Dentener F et al (2012) Effects of business-as-usual anthropogenic emissions on air quality